New: Please Join us on Facebook! Death from Ritalin
The Truth Behind ADHD
Share with your Facebook Friends  

National Alliance against Mandated Mental Health
Screening and Psychiatric Drugging of Children
 Share
 
 
Children's Deaths Caused From ADD & ADHD Drugs
A special savings for anybody who orders Focus Formula either through our website or one of our facebook links. Enter the promo code: SAV20FOCUS to receive a 20% discount and free shipping on any size order.
ADHD Help
Advertising
A-Z Content
Education Articles
Testimonials
Panasonic Massage
Chair Divisio
n
Drug Information
We have 3 Stand
Alone Pages Below

1. Alternative
Therapies

2. Homeopathy

3. Therapeutic
Boarding Schools

We have 10 National Directories Below
Allergists
Chiropractic Neurologist
Chiropractors
Hearing Specialists
Holistic Medical Doctors
Learning Centers
Nutritionists
Osteopathic Physicians
Speech and Language
Vision Specialists
Relevant Sites
 Dr. Fred Baughman Jr. MD, he has been a adult & child neurologist, in private practice, for 35 years
Block Center
Wildest Colts
Gifted Children
Methylphenidate
Annie Armen Live
Peter Breggin, M.D.
Report Site Bugs. Email
web-admin@ritalindeath.com

Can Ritalin cause cancer?
Cancer Prevention Coalition

American Academy of Pediatrics Guidelines for Treating Disorders in Children with Ritalin Ignores Evidence of Cancer Risks warns Samuel S. Epstein", default", M.D.

Chicago, 10/04/01. ----- Based on an industry-funded multi-university trial on 282 pre-teen children treated with Ritalin for attention deficit/hyperactivity disorders (ADHD), just published in Pediatrics, the American Academy of Pediatrics has endorsed the use of the drug. However, the Academy ignores clear evidence of the drug's cancer risks of which parents, teachers and school nurses, besides most pediatricians and psychiatrists, still remain uninformed and unaware.

Some 40 years after the drug was first marketed by Ciba Geigy, carcinogenicity tests were conducted at the taxpayers expense by the National Toxicology Program, the results of which were published in 1995. Adult mice were fed Ritalin over a two-year period at dosages close to those prescribed to children. The mice developed a statistically significant incidence of liver abnormalities and tumors, including highly aggressive rare cancers known as hepatoblastomas. These findings are particularly disturbing as the tests were conducted on adult, rather than young mice which would be expected to be much more sensitive to carcinogenic effects. The National Toxicology Program concluded that Ritalin is a "possible human carcinogen," and recommended the need for further research. While still insisting that the drug is safe, the Food and Drug Administration admitted that these findings signal "carcinogenic potential," and required a statement to this effect in the drug's package insert. However, these inserts are not seen by parents or nurses.

The Physicians' Desk Reference admits evidence on the carcinogenicity of Ritalin, now manufactured by Novartis, qualified by the statement that "the significance of these results is unknown," apparently not recognizing that this is more alarming than reassuring. Apart from cancer risks, there is also suggestive evidence that Ritalin induces genetic damage in blood cells of Ritalin-treated children.

Concerns on Ritalin's cancer risk are more acute in view of the millions of children treated annually with the drug and the escalating incidence of childhood cancer, by some 35% over the last few decades, quite apart from delayed risks of cancer in adult life. These risks are compounded by the availability of alternative safe and effective procedures, notably behavior modification and biofeedback.

There is no justification for prescribing Ritalin, even by highly qualified pediatricians and psychiatrists, unless parents have been explicitly informed of the drug's cancer risks. Otherwise, prescribing Ritalin constitutes unarguable medical malpractice.

Contact: Samuel S. Epstein, M.D., emeritus Professor Environmental Medicine, University of Illinois School of Public Health, Chicago, and Chairman, Cancer Prevention Coalition, 2121 W. Taylor Street (MC 922), Chicago, IL 60612, phone 312-996-2297, fax 312-996-1374, email epstein@uic.edu

Source: University of Texas Medical Branch at Galveston Released: Thu 24-Feb-2005, 14:00 ET

Study Shows Methylphenidate Linked to Chromosomal Changes

Libraries
Medical News
Keywords
RITALIN GENETIC DAMAGE CANCER METHYLPHENIDATE ADHD

Contact Information

Available for logged-in reporters only

Description

A new study found that every one of a dozen children treated for attention deficit/ hyperactivity disorder with methylphenidate experienced a threefold increase in levels of chromosome abnormalities—occurrences associated with increased risks of cancer and other adverse health effects.

swise — In a small but startling preliminary new study, Texas researchers have found that after just three months, every one of a dozen children treated for attention deficit/hyperactivity disorder (ADHD) with the drug methylphenidate experienced a threefold increase in levels of chromosome abnormalities—occurrences associated with increased risks of cancer and other adverse health effects.

The researchers say that to their knowledge this is the first study addressing the potential chromosome-breaking effects associated with treatment of children with methylphenidate, the generic name for a group of drugs that includes Ritalin, Concerta, Metadate CD and others.

Methylphenidate is the most widely prescribed of a class of amphetamine-like drugs used to treat ADHD, with more than 10 million prescriptions written for it in 1996 alone. Between 1991 and 1999, United States sales of methylphenidate increased more than 500 percent.

Researchers at The University of Texas M.D. Anderson Cancer Center in Houston and the University of Texas Medical Branch at Galveston (UTMB) reported their detection of the chromosome abnormalities in the journal Cancer Letters. Their peer-reviewed paper is to be published several months hence, but the journal editors have made it available online in the journal’s “articles in press” section.

The authors said they undertook the study because, even though methylphenidate has been approved for human use for more than 50 years, “there are surprisingly few studies” in either animals or human beings “on the potential for serious side effects,” such as causing mutations and cancer. In 1996, a report discussing several two-year-long animal studies showed that the highest levels of methylphenidate tested caused liver tumors in male and female mice. However, similar studies in rats showed no such tumors.

The new Texas study involved researchers drawing blood from children diagnosed with ADHD before they began taking methylphenidate in order to get a baseline level of chromosomal abnormalities. Three months after the children had begun taking the drug, the researchers drew the children’s blood and tested it a second time. Chromosomes are the bodies within cells that carry the genes and genetic information. All 12 of the children whose before-and-after blood cells were studied were treated with normal therapeutic doses of methylphenidate.

Most of the abnormalities found in the studied blood cells consisted of chromosome breaks “and a higher frequency of aberrations is reported to be associated with an increased risk of cancer down the line,” said lead author Randa A. El-Zein, M.D., Ph.D., an assistant professor of epidemiology at M.D. Anderson who performed the blood studies using several techniques.

“It was pretty surprising that all of the children taking methylphenidate showed an increase in chromosome abnormalities in a relatively short period of time,” El-Zein said.

UTMB Professor of Environmental Toxicology Marvin Legator, the study’s principal investigator and senior author, cautioned, “This study doesn’t mean that these kids are going to get cancer, but it does mean they are exposed to an additional risk factor, assuming that this study holds up.” Of the 53 known human carcinogens, Legator said 48 could be detected using the chromosome analysis methods employed in this study.

El-Zein stressed that much larger studies at several medical centers are needed to confirm the results of this study and to answer other questions not addressed by it. One of these issues is the question of what happens when patients stop taking methylphenidate. “Do the levels of chromosome abnormalities go back to normal?” El-Zein said. “We don’t know.”

Parents should respond cautiously to this preliminary study, El-Zein said, noting that there are few alternatives to methylphenidate for treating ADHD.

Asked what he would do in response to the study if his child were on methylphenidate, co-author Matthew J. Hay, a UTMB pediatrician who treated all the children who participated in the study, was equally guarded. “Twelve kids with one physician in one county is too small a sample to base a decision on,” he said. “If my child were on the medication and were doing well, I wouldn’t take him off it” unless additional studies showed similar effects.

The Cancer Letters article by Randa A. El-Zein, Sherif Z. Abdel-Rahman, Matthew J. Hay, Mirtha S. Lopez, Melissa L. Bondy, Debra L. Morris and Marvin S. Legator can be found on the Web by clicking the “Articles in Press” button on ScienceDirect’s Cancer Letters page (http://www.sciencedirect.com/science/journal/03043835).

© 2001-2010 National Alliance against Mandated Mental Health Screening & Psychiatric Drugging of Children. All rights reserved.

Home / About Us / Content / Mission / ADHD Help / Advertising / ADHD Message Board

 

hosted by outflow technologies providing business solutions to results through technology solutions.

 

Don't let psychiatry use their Crystal diagnosis ball on your child!
If you are being harassed to medicate your child for ADHD?
Tell Them Where To Go www.RitalinDeath.com

 

Disclaimer