Information about Wellbutrin XL: Includes the warnings, side effects, precautions and drug interactions.
IMPORTANT NOTE | TITLE | HOW TO PRONOUNCE | COMMON BRAND NAMES | USES | OTHER USES | HOW TO TAKE | SIDE EFFECTS | PRECAUTIONS | DRUG INTERACTIONS | OVERDOSE | NOTES | MISSED DOSE | STORAGE
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
TITLE BUPROPION EXTENDED RELEASE - ORAL (ANTIDEPRESSANT)
HOW TO PRONOUNCE (byou-PRO-pee-on)
COMMON BRAND NAMES Wellbutrin XL
This medication is used to treat major depression. This
medication works by helping to restore the balance of natural chemicals in the
OTHER USES This medication may also be used for quitting smoking.
HOW TO TAKE
Take this medication by mouth, usually once daily with
or without food. If nausea occurs, you may take this drug with food. Do not
crush, chew or break the tablets. Swallow tablets whole. Since this drug may
cause sleeplessness at first, it is best not to take near bedtime. The dosage is
based on your medical condition and response to therapy. Do not take more or
less medication than prescribed. Taking more than the recommended dose of
bupropion will increase your risk of having a seizure. The maximum dose of
bupropion is 300 -450 milligrams per day, depending on your medical condition
(stop smoking therapy vs. psychiatric conditions). If you have very severe liver
disease, the maximum dose is 150 milligrams every other day. Do not stop taking
this medication without notifying your doctor. Use this medication regularly in
order to get the most benefit from it. To help you remember, use it at the same
time each day. It may take 4 weeks or more before the full effects of this
medication are noticed. Read the patient information leaflet provided by your
Dry mouth, nausea, vomiting, stomach/abdominal pain,
flushing, headache/migraine, loss of appetite, trouble sleeping, increased
sweating, strange taste in mouth, weakness, drowsiness, or blurred vision may
occur. If any of these effects persist or worsen, notify your doctor or
pharmacist promptly. Tell your doctor immediately if any of these unlikely but
serious side effects occur: dizziness, fainting, chest pain, fast heartbeat,
tremor, unusual weight loss or gain, ringing in the ears, severe headache,
unusual or severe mental/mood changes (e.g., hallucinations, anxiety,
nervousness, agitation, confusion, restlessness), decreased sex drive,
difficulty urinating. Seek immediate medical attention if the following
infrequent but serious side effect occurs: seizures. Bupropion should be stopped
permanently if you have a seizure while taking the medication. An allergic
reaction to this drug is unlikely, but seek immediate medical attention if it
occurs. Symptoms of an allergic reaction include: rash, itching, swelling,
severe dizziness, trouble breathing, muscle aches, joint pain, fever. An empty
tablet shell may appear in your stool. This is harmless. If you notice other
effects not listed above, contact your doctor or pharmacist.
Before taking bupropion, tell your doctor or pharmacist
if you are allergic to it or if you have any other allergies. This medication
should not be used if you have certain medical conditions. Before using this
medicine, consult your doctor or pharmacist if you have: seizures, eating
disorders (e.g., bulimia, anorexia nervosa). This medication should not be used
if you are suddenly stopping regular use of sedatives (e.g., benzodiazepines
such as diazepam) or alcohol, since doing so creates a higher risk of seizures.
Before using this medication, tell your doctor or pharmacist your medical
history, especially of: head injury, brain tumor, liver problems, heart disease,
high blood pressure, kidney problems, any mental conditions, diabetes,
alcohol/drug dependence, intention to quit smoking. This drug may make you dizzy
or drowsy; use caution engaging in activities requiring alertness such as
driving or using machinery. Limit or avoid consumption of alcoholic beverages.
Alcohol can increase your risk of seizures. Do not take this medicine with any
other product containing bupropion (e.g., drugs to help quit smoking) since
large doses of bupropion are more likely to cause seizures. Though uncommon,
depression can lead to thoughts or attempts of suicide. Tell your doctor
immediately if you have any suicidal thoughts, worsening depression, or any
other mental/mood changes (including new or worsening anxiety, agitation, panic
attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive
actions, severe restlessness, rapid speech). Keep all medical appointments so
your healthcare professional can monitor your progress closely and adjust/change
your medication if needed. This medication should be used only when clearly
needed during pregnancy. Discuss the risks and benefits with your doctor.
Bupropion passes into breast milk. Because of the potential risk to the infant,
breast-feeding is not recommended while using this drug.
This drug should not be used with the following
medications because very serious interactions may occur: MAO inhibitors (e.g.,
furazolidone, linezolid, moclobemide, phenelzine, procarbazine, selegiline,
isocarboxazid, tranylcypromine). If you are currently using or have recently
stopped taking an MAO inhibitor within the last 14 days, tell your doctor or
pharmacist before starting bupropion. Before using this medication, tell your
doctor or pharmacist of all prescription and nonprescription products you may
use, especially of: warfarin, levodopa, ritonavir, diabetes medications (e.g.,
hypoglycemic agents such as glyburide, glipizide, or insulin), amantadine,
adrenaline-like stimulants (e.g., ephedrine), products containing nicotine
(e.g., patches, gum, or spray), regular use of sedatives (e.g., diazepam). Also
tell your doctor if you are taking any drugs which are affected by certain liver
enzymes (CYP 2D6 or CYP 2B6 substrates, inhibitors, or inducers), such as:
certain SSRI antidepressants (e.g., paroxetine, fluoxetine, sertraline),
beta-blockers (e.g., metoprolol), antiarrhythmics (e.g., propafenone,
flecainide), orphenadrine, thiotepa, cyclophosphamide, carbamazepine,
phenobarbital, phenytoin, valproic acid. Also report the use of drugs which
might increase seizure risk (decrease seizure threshold) when combined with
bupropion such as phenothiazines (e.g., thioridazine), tricyclic antidepressants
(e.g., amitriptyline), isoniazid (INH), or theophylline among others. Consult
your doctor or pharmacist for details. Excess caffeine intake can increase the
chance of seizures with this drug. Check all nonprescription/prescription drug
labels for caffeine. Consult your doctor or pharmacist. Do not start or stop any
medicine without doctor or pharmacist approval.
If overdose is suspected, contact your local poison
control center or emergency room immediately. US residents can call the US
national poison hotline at 1-800-222-1222. Canadian residents should call their
local poison control center directly. Symptoms of overdose may include seizures,
severe confusion, hallucinations, rapid heart rate, and loss of consciousness.
Do not share this medication with others. Laboratory
and/or medical tests (e.g., blood pressure monitoring) should be performed
periodically to monitor your progress or check for side effects. Consult your
doctor for more details.
If you miss a dose, skip the missed dose and resume your
usual dosing schedule. Do not double the dose to catch up. Taking too much of
this medication can increase your chance of having a seizure.
Store at room temperature at 77 degrees F (25 degrees C)
away from light and moisture. Brief storage between 59 and 86 degrees F (15-30
degrees C) is permitted. Do not store in the bathroom. Keep all medicines away
from children and pets.